Egeblad, M., Ewald, A. J., Askautrud, H. A., Truitt, M. L., Welm, B. E., Bainbridge, E., Peeters, G., Krummel, M. F., Werb, Z. (2008) Carcinoma-associated fibroblasts in different tumor microenvironments. [Video]
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Abstract
Three microenvironments were imaged in the same mouse before and after injection of dextran. Left panel: Most fibroblast specific protein1 (FSP1)+ cells (green) are non-migratory in the adipogenic stroma at the border of a hyperplastic lesion (blue). Middle panel: a few migratory FSP1+ cells are seen at the border of an early carcinoma (blue) among non-migratory FSP1+ and FSP1+/dextran+ cells. Right panel: Most FSP1+ cells that have infiltrated the carcinoma mass are non-migratory. Imaged in an MMTV-PyMT;ACTB-ECFP;Fsp1+.+.EGFP mouse injected intravenously 1 hours 41 minutes after imaging was initiated with rhodamine-conjugated dextran (red) to mark first blood vessels and then macrophages (FSP1+/dextran+; green/red). From Egeblad et al. (2008) Dis. Model. Mech., 1 155-167.
| Item Type: | Video |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders Investigative techniques and equipment Investigative techniques and equipment > microscopy > flourescence microscopy Investigative techniques and equipment > microscopy > immunoflourescence microscopy Investigative techniques and equipment > microscopy |
| CSHL Authors: | |
| Communities: | CSHL labs > Egeblad lab |
| Depositing User: | Matt Covey |
| Date: | 2008 |
| Date Deposited: | 26 Apr 2013 16:25 |
| Last Modified: | 26 Apr 2013 16:25 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/28264 |
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