Targeting the CREB pathway for memory enhancers

Tully, T., Bourtchouladze, R., Scott, R., Tallman, J. (2003) Targeting the CREB pathway for memory enhancers. Nature Reviews Drug Discovery, 2 (4). pp. 267-277. ISSN 1474-1776

URL: http://www.ncbi.nlm.nih.gov/pubmed/12669026
DOI: 10.1038/nrd1061

Abstract

Today, the clinical notion of 'memory disorder' is largely synonymous with 'Alzheimer's disease.' Only 50% of all dementias are of the Alzheimer's type though, and dementias represent only the more severe of all learning/memory disorders that derive from heredity, disease, injury or age. Perhaps as many as 30 million Americans suffer some type of clinically recognized memory disorder. To date, therapeutic drugs of only one class have been approved for the treatment of Alzheimer's disease. Fortunately, basic research during the past 25 years has begun to define a 'chemistry of brain plasticity,' which is suggesting new gene targets for the discovery of memory enhancers.

Item Type: Paper
Uncontrolled Keywords: LONG-TERM-MEMORY ELEMENT-BINDING PROTEIN EXPERIENCE-DEPENDENT PLASTICITY MEDIATED GENE-EXPRESSION CAMP-RESPONSIVE ELEMENT SYNAPTIC PLASTICITY BEHAVIORAL PHARMACOLOGY TRANSCRIPTION FACTORS ALZHEIMERS-DISEASE MOTOR CORTEX
Subjects: diseases & disorders > mental disorders > delirium dementia cognitive disorders > Alzheimer's disease
diseases & disorders > mental disorders > delirium dementia cognitive disorders
diseases & disorders > mental disorders
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: Matt Covey
Date Deposited: 27 Jun 2013 19:47
Last Modified: 27 Jun 2013 19:47
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27908

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