Genetic and epigenetic regulation of stem cell homeostasis in plants

Lodha, M., Marco, C. F., Timmermans, M. C. P. (2008) Genetic and epigenetic regulation of stem cell homeostasis in plants. Cold Spring Harbor Symposia on Quantitative Biology, 73. pp. 243-51. ISSN 00917451 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/19150966
DOI: 10.1101/sqb.2008.73.044

Abstract

Plants generate new organs through the activity of small populations of stem cells present in specialized niches called meristems. Stem cell homeostasis is attained by dynamic regulatory networks involving transcriptional regulators, hormones, and other intercellular signals that specify cell fate and convey positional information to the apical stem cells and the organizing center located immediately below. The balance between stem cell maintenance within the shoot apical meristem (SAM) and differentiation of cells that are displaced from the niche to form new organs involves the epigenetic silencing of stem cell regulatory genes. Recent advances have identified highly conserved chromatin remodeling factors as epigenetic regulators of stem cell fate that confer plasticity in plant development and ensure the stable inheritance of repressed expression states during organogenesis. These advances reveal that common mechanisms contribute to stem cell homeostasis in plants and animals.

Item Type: Paper
Uncontrolled Keywords: Epigenesis, Genetic Feedback, Biochemical Gene Expression Regulation, Plant Genes, Plant Homeodomain Proteins/genetics/metabolism Homeostasis Meristem/cytology/metabolism Models, Biological Plant Proteins/genetics/metabolism Plants/*cytology/*genetics/metabolism Stem Cells/*cytology/*metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics

organism description > plant
therapies > stem cells
CSHL Authors:
Communities: CSHL labs > Timmermans lab
CSHL Post Doctoral Fellows
Depositing User: Matt Covey
Date: 2008
Date Deposited: 26 Feb 2013 20:54
Last Modified: 02 May 2013 20:15
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27532

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