Optimal axonal and dendritic branching strategies during the development of neural circuitry

Tsigankov, D. N., Koulakov, A. A. (November 2009) Optimal axonal and dendritic branching strategies during the development of neural circuitry. Front Neural Circuits, 3. p. 18. ISSN 1662-5110 (Electronic)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/19915729
DOI: 10.3389/neuro.04.018.2009

Abstract

In developing brain, axons and dendrites are capable of connecting to each other with high precision. Imaging of axonal and dendritic dynamics in vivo shows that the majority of axonal and dendritic branches are formed 'in error', only to be retracted later. The functional significance of the overproduction of branches is not clear. Here we show that branching of both axons and dendrites can accelerate finding appropriate synaptic targets during the development of neuronal circuitry. We suggest that branching rules implemented by axons and dendrites minimize the number of erroneous branches. We find that optimal branching rules are different for axons and dendrites in agreement with experimentally observed branch dynamics. Thus, our studies suggest that the developing neural system employs a set of sophisticated computational strategies that facilitate the formation of required circuitry in the fastest and most frugal way.

Item Type: Paper
Additional Information: This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.
Uncontrolled Keywords: retinocollicular projections topographic mapping axonal and dendritic branching synaptotropic computer simulation
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > axon
organs, tissues, organelles, cell types and functions > cell types and functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors

organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits

organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:
Communities: CSHL labs > Koulakov lab
Depositing User: Matt Covey
Date: 3 November 2009
Date Deposited: 20 Feb 2013 16:12
Last Modified: 20 Feb 2013 16:12
PMCID: PMC2776482
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27428

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