A New Tumor Suppressor That Regulates Tissue Architecture

Muthuswamy, S. K. (May 2009) A New Tumor Suppressor That Regulates Tissue Architecture. PLoS Medicine, 6 (5). e1000073.

[img]
Preview
PDF (Paper)
Muthuswamy PLoS Med 2009.pdf - Published Version

Download (71Kb) | Preview
URL: http://www.ncbi.nlm.nih.gov/pubmed/19536324
DOI: 10.1371/journal.pmed.1000073

Abstract

Pathologists use loss of normal tissue architecture as a key criterion to identify and categorize disease states. Epithelia in all glandular structures in vivo have a characteristic organization where they line a central lumen and are involved in absorptive and/or secretory functions. Under some physiological conditions—such as pregnancy, wound healing, and the periodic tissue remodeling that occurs in tissues such as colon—there is a significant increase in the rate of cell proliferation. Although the proliferation rate in these physiological conditions is higher than that seen under disease states, the overall tissue size and structure are maintained. Such maintenance of size/structure occurs because the increased proliferation is tightly coupled with tissue morphogenesis programs, resulting in remodeling of normal tissue architecture.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > suppressor
CSHL Authors:
Communities: CSHL labs > Muthuswamy lab
Depositing User: Matt Covey
Date: 5 May 2009
Date Deposited: 20 Feb 2013 19:18
Last Modified: 20 Feb 2013 19:18
PMCID: PMC2669713
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27424

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving