The piRNA pathway in flies: highlights and future directions

Guzzardo, P. M., Muerdter, F., Hannon, G. J. (January 2013) The piRNA pathway in flies: highlights and future directions. Curr Opin Genet Dev, 23 (1). pp. 44-52. ISSN 1879-0380 (Electronic)0959-437X (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/23317515
DOI: 10.1016/j.gde.2012.12.003

Abstract

Piwi proteins, together with their bound Piwi-interacting RNAs, constitute an evolutionarily conserved, germline-specific innate immune system. The piRNA pathway is one of the key mechanisms for silencing transposable elements in the germline, thereby preserving genome integrity between generations. Recent work from several groups has significantly advanced our understanding of how piRNAs arise from discrete genomic loci, termed piRNA clusters, and how these Piwi-piRNA complexes enforce transposon silencing. Here, we discuss these recent findings, as well as highlight some aspects of piRNA biology that continue to escape our understanding.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
organism description > animal > insect > Drosophila
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
organism description > animal
organism description > animal > insect
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > piRNA
CSHL Authors:
Communities: CSHL labs > Hannon lab
Watson School > Publications
Depositing User: Matt Covey
Date: 11 January 2013
Date Deposited: 11 Feb 2013 17:14
Last Modified: 07 Apr 2015 14:42
PMCID: PMC3621807
Related URLs:
URI: http://repository.cshl.edu/id/eprint/27238

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