Guzzardo, P. M., Muerdter, F., Hannon, G. J. (January 2013) The piRNA pathway in flies: highlights and future directions. Curr Opin Genet Dev, 23 (1). pp. 44-52. ISSN 1879-0380 (Electronic)0959-437X (Linking)
Abstract
Piwi proteins, together with their bound Piwi-interacting RNAs, constitute an evolutionarily conserved, germline-specific innate immune system. The piRNA pathway is one of the key mechanisms for silencing transposable elements in the germline, thereby preserving genome integrity between generations. Recent work from several groups has significantly advanced our understanding of how piRNAs arise from discrete genomic loci, termed piRNA clusters, and how these Piwi-piRNA complexes enforce transposon silencing. Here, we discuss these recent findings, as well as highlight some aspects of piRNA biology that continue to escape our understanding.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics organism description > animal organism description > animal > insect bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > piRNA |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab School of Biological Sciences > Publications |
| Depositing User: | Matt Covey |
| Date: | 11 January 2013 |
| Date Deposited: | 11 Feb 2013 17:14 |
| Last Modified: | 07 Apr 2015 14:42 |
| PMCID: | PMC3621807 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27238 |
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