RNA interference: A promising approach to antiviral therapy?

Silva, J. M., Hammond, S. M., Hannon, G. J. (2002) RNA interference: A promising approach to antiviral therapy? Trends in Molecular Medicine, 8 (11). pp. 505-508. ISSN 14714914 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/12421679
DOI: 10.1016/s1471-4914(02)02421-8

Abstract

RNA interference (RNAi) has developed into a powerful tool for probing gene function. Recently, several reports have demonstrated the use of RNAi for attenuation of viral infection and replication in cultured cells. Furthermore, RNAi has been shown to suppress gene expression in adult animals. Although these results suggest that RNAi might become a novel therapeutic approach, significant hurdles must still be overcome before RNAi can be exploited in the fight against human disease.

Item Type: Paper
Uncontrolled Keywords: RNA antivirus agent complementary RNA double stranded RNA microRNA small interfering RNA untranslated RNA article cellular immunity gene function gene repression gene silencing mammal cell nonhuman RNA interference virus attenuation virus infection virus replication virus resistance animal drug therapy human physiology Animalia Mammalia RNA viruses Animals Antiviral Agents Humans MicroRNAs RNA, Antisense RNA, Double-Stranded RNA, Small Interfering RNA, Untranslated Virus Diseases
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
Investigative techniques and equipment
Investigative techniques and equipment > RNAI
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
therapies
diseases & disorders > viral diseases
organism description > virus > viral transfection
organism description > virus
CSHL Authors:
Depositing User: Matt Covey
Date: 2002
Date Deposited: 09 Jan 2013 16:58
Last Modified: 09 Jan 2013 16:58
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26462

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