Caspases: enemies within

Thornberry, N. A., Lazebnik, Y. (1998) Caspases: enemies within. Science, 281 (5381). pp. 1312-1316. ISSN 0036-8075

URL: http://www.ncbi.nlm.nih.gov/pubmed/9721091
DOI: 10.1126/science.281.5381.1312

Abstract

Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

Item Type: Paper
Uncontrolled Keywords: Animals Apoptosis Catalysis Cysteine Endopeptidases Cysteine Proteinase Inhibitors Drug Therapy Enzyme Activation Enzyme Precursors Humans Neoplasms Substrate Specificity
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions
CSHL Authors:
Communities: CSHL labs > Labeznik lab
Depositing User: Matt Covey
Date: 1998
Date Deposited: 12 Dec 2012 17:30
Last Modified: 12 Dec 2012 17:30
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26397

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