Nuclear choreography: interpretations from living cells

Janicki, S. M., Spector, D. L. (2003) Nuclear choreography: interpretations from living cells. Current Opinion in Cell Biology, 15 (2). pp. 149-157. ISSN 0955-0674

URL: http://www.ncbi.nlm.nih.gov/pubmed/12648670
DOI: 10.1016/S0955-0674(03)00012-7

Abstract

The advent of green fluorescent protein technology, its use in photobleaching experiments and the development of methods to rapidly acquire images and analyze complex datasets have opened the door to unraveling the mechanisms of nuclear functions in living cells. Studies over the past few years have characterized the movement of chromatin, nuclear proteins and nuclear bodies and, in some cases, correlated their dynamics with energy dependence, cell cycle progression, developmental changes, factor targeting and nuclear position. The mechanisms by which nuclear components move or are restrained have important implications for understanding not only the efficacy of nuclear functions but also the regulation of developmental programs and cellular growth.

Item Type: Paper
Uncontrolled Keywords: Animals Cell Cycle Cell Movement Cell Nucleus Cell Nucleus Structures Chromatin Eukaryotic Cells Humans Nuclear Proteins Transcription, Genetic
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
Investigative techniques and equipment
Investigative techniques and equipment > microscopy > flourescence microscopy
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > green fluorescent protein
Investigative techniques and equipment > microscopy > immunoflourescence microscopy
CSHL Authors:
Communities: CSHL labs > Spector lab
Depositing User: Matt Covey
Date Deposited: 10 Dec 2012 20:01
Last Modified: 29 Jan 2015 16:00
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26354

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