Transposable elements and the epigenetic regulation of the genome

Slotkin, R. Keith, Martienssen, Robert (April 2007) Transposable elements and the epigenetic regulation of the genome. Nat Rev Genet, 8 (4). pp. 272-85. ISSN 1471-0056 (Print)

URL: http://www.ncbi.nlm.nih.gov/pubmed/17363976
DOI: 10.1038/nrg2072

Abstract

Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the expression and mobility of transposable elements (TEs). Owing to their ability to recruit the silencing machinery, TEs have served as building blocks for epigenetic phenomena, both at the level of single genes and across larger chromosomal regions. Important progress has been made recently in understanding these silencing mechanisms. In addition, new insights have been gained into how this silencing has been co-opted to serve essential functions in 'host' cells, highlighting the importance of TEs in the epigenetic regulation of the genome.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA expression > transposable elements
CSHL Authors:
Communities: CSHL labs > Martienssen lab
Depositing User: CSHL Librarian
Date: April 2007
Date Deposited: 07 Nov 2011 18:42
Last Modified: 09 Apr 2014 20:28
Related URLs:
URI: http://repository.cshl.edu/id/eprint/23140

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving