Flexible control of mutual inhibition: a neural model of two-interval discrimination

Machens, C. K., Romo, R., Brody, C. D. (2005) Flexible control of mutual inhibition: a neural model of two-interval discrimination. Science, 307 (5712). pp. 1121-4. ISSN 1095-9203 (Electronic)

URL: http://www.scopus.com/record/display.url?eid=2-s2....
DOI: 10.1126/science.1104171

Abstract

Networks adapt to environmental demands by switching between distinct dynamical behaviors. The activity of frontal-lobe neurons during two-interval discrimination tasks is an example of these adaptable dynamics. Subjects first perceive a stimulus, then hold it in working memory, and finally make a decision by comparing it with a second stimulus. We present a simple mutual-inhibition network model that captures all three task phases within a single framework. The model integrates both working memory and decision making because its dynamical properties are easily controlled without changing its connectivity. Mutual inhibition between nonlinear units is a useful design motif for networks that must display multiple behaviors.

Item Type: Paper
Uncontrolled Keywords: Algorithms Animals Cognition Computer Simulation Decision Making Discrimination (Psychology) Frontal Lobe cytology physiology Macaca Mathematics Memory Models Neurological Nerve Net physiology Neural Inhibition Neural Networks (Computer) Neurons physiology Neurons Afferent physiology Nonlinear Dynamics Prefrontal Cortex cytology physiology Psychomotor Performance Somatosensory Cortex cytology physiology
Subjects: bioinformatics > genomics and proteomics > annotation > map annotation
organism description > animal behavior > memory
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Brody lab
Depositing User: CSHL Librarian
Date Deposited: 10 Jan 2012 16:05
Last Modified: 10 Jan 2012 16:05
URI: http://repository.cshl.edu/id/eprint/22641

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