Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective

Ruthazer, E. S., Cline, H. T. (2004) Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective. J Neurobiol, 59 (1). pp. 134-46. ISSN 0022-3034 (Print)

URL: http://www.scopus.com/record/display.url?eid=2-s2....
DOI: 10.1002/neu.10344

Abstract

The development of orderly topographic maps in the central nervous system (CNS) results from a collaboration of chemoaffinity cues that establish the coarse organization of the projection and activity-dependent mechanisms that fine-tune the map. Using the retinotectal projection as a model system, we describe evidence that biochemical tags and patterned neural activity work in parallel to produce topographically ordered axonal projections. Finally, we review recent experiments in other CNS projections that support the proposition that cooperation between molecular guidance cues and activity-dependent processes constitutes a general paradigm for CNS map formation.

Item Type: Paper
Uncontrolled Keywords: Animals Axons physiology Brain Mapping Cerebral Cortex anatomy & histology physiology Eye Models Neurological Neurons physiology Retina cytology physiology Superior Colliculus cytology physiology Thalamus physiology Visual Pathways physiology
Subjects: bioinformatics > genomics and proteomics > annotation > map annotation
organs, tissues, organelles, cell types and functions > tissues types and functions > axon
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
CSHL Authors:
Communities: CSHL labs > Cline lab
Depositing User: CSHL Librarian
Date Deposited: 25 Jan 2012 19:13
Last Modified: 25 Jan 2012 19:13
URI: http://repository.cshl.edu/id/eprint/22469

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