Ruthazer, E. S., Cline, H. T. (April 2004) Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective. J Neurobiol, 59 (1). pp. 134-46. ISSN 0022-3034 (Print)
Abstract
The development of orderly topographic maps in the central nervous system (CNS) results from a collaboration of chemoaffinity cues that establish the coarse organization of the projection and activity-dependent mechanisms that fine-tune the map. Using the retinotectal projection as a model system, we describe evidence that biochemical tags and patterned neural activity work in parallel to produce topographically ordered axonal projections. Finally, we review recent experiments in other CNS projections that support the proposition that cooperation between molecular guidance cues and activity-dependent processes constitutes a general paradigm for CNS map formation.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Axons physiology Brain Mapping Cerebral Cortex anatomy & histology physiology Eye Models Neurological Neurons physiology Retina cytology physiology Superior Colliculus cytology physiology Thalamus physiology Visual Pathways physiology |
| Subjects: | bioinformatics > genomics and proteomics > annotation > map annotation organs, tissues, organelles, cell types and functions > tissues types and functions > axon organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons |
| CSHL Authors: | |
| Communities: | CSHL labs > Cline lab |
| Depositing User: | CSHL Librarian |
| Date: | April 2004 |
| Date Deposited: | 25 Jan 2012 19:13 |
| Last Modified: | 25 Jan 2012 19:13 |
| URI: | https://repository.cshl.edu/id/eprint/22469 |
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