Dynamic interplay between the collagen scaffold and tumor evolution

Egeblad, M., Rasch, M. G., Weaver, V. M. (October 2010) Dynamic interplay between the collagen scaffold and tumor evolution. Current Opinion in Cell Biology, 22 (5). pp. 697-706. ISSN 0955-0674

URL: http://www.ncbi.nlm.nih.gov/pubmed/20822891
DOI: 10.1016/j.ceb.2010.08.015

Abstract

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the ECM has been thought of primarily as a physical scaffold that binds cells and tissues together. However, the ECM also elicits biochemical and biophysical signaling. Controlled proteolysis and remodeling of the ECM network regulate tissue tension, generate pathways for migration, and release ECM protein fragments to direct normal developmental processes such as branching morphogenesis. Collagens are major components of the ECM of which basement membrane type IV and interstitial matrix type I are the most prevalent. Here we discuss how abnormal expression, proteolysis and structure of these collagens influence cellular functions to elicit multiple effects on tumors, including proliferation, initiation, invasion, metastasis, and therapy response.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > analysis and processing > NETBAG
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase
CSHL Authors:
Communities: CSHL labs > Egeblad lab
Depositing User: CSHL Librarian
Date: October 2010
Date Deposited: 29 Sep 2011 19:42
Last Modified: 14 Mar 2013 20:16
PMCID: PMC2948601
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15405

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