Evolutionary impact of limited splicing fidelity in mammalian genes

Zhang, C., Krainer, A. R., Zhang, M. Q. (October 2007) Evolutionary impact of limited splicing fidelity in mammalian genes. Trends Genet, 23 (10). pp. 484-488. ISSN 0168-9525 (Print)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/17719121
DOI: 10.1016/j.tig.2007.08.001

Abstract

The functional significance of most alternative splicing (AS) events, especially frame-shifting ones, has been controversial. Using human-mouse comparison, we demonstrate that frame-preserving AS events adapt and get fixed more rapidly than frame-shifting AS events; selection for smaller exon size is stronger in frame-preserving exons than in frame-shifting ones. These results suggest AS events introducing mild changes are generally favored during evolution and explain the excess of shorter, frame-preserving cassette exons in present mammalian genomes.

Item Type: Paper
Uncontrolled Keywords: MESSENGER-RNA DECAY SELECTION PRESSURE HUMAN GENOME EXON DATABASE EVENTS BIRTH MOUSE
Subjects: bioinformatics > genomics and proteomics > databases
bioinformatics > genomics and proteomics
organism description > animal > mammal > primates > hominids > human
organism description > animal > mammal > rodent > mouse
CSHL Authors:
Communities: CSHL labs > Zhang lab
CSHL labs > Krainer lab
Depositing User: CSHL Librarian
Date: October 2007
Date Deposited: 30 Aug 2011 17:48
Last Modified: 31 Mar 2014 20:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/15290

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