Zhang, C., Krainer, A. R., Zhang, M. Q. (October 2007) Evolutionary impact of limited splicing fidelity in mammalian genes. Trends Genet, 23 (10). pp. 484-488. ISSN 0168-9525 (Print)
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Abstract
The functional significance of most alternative splicing (AS) events, especially frame-shifting ones, has been controversial. Using human-mouse comparison, we demonstrate that frame-preserving AS events adapt and get fixed more rapidly than frame-shifting AS events; selection for smaller exon size is stronger in frame-preserving exons than in frame-shifting ones. These results suggest AS events introducing mild changes are generally favored during evolution and explain the excess of shorter, frame-preserving cassette exons in present mammalian genomes.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | MESSENGER-RNA DECAY SELECTION PRESSURE HUMAN GENOME EXON DATABASE EVENTS BIRTH MOUSE |
| Subjects: | bioinformatics > genomics and proteomics > databases bioinformatics > genomics and proteomics organism description > animal > mammal > primates > hominids > human organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL labs > Zhang lab CSHL labs > Krainer lab |
| Depositing User: | CSHL Librarian |
| Date: | October 2007 |
| Date Deposited: | 30 Aug 2011 17:48 |
| Last Modified: | 31 Mar 2014 20:55 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15290 |
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