Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

Gao, D., Nolan, D. J., Mellick, A. S., Bambino, K., McDonnell, K., Mittal, V. (January 2008) Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science, 319 (5860). pp. 195-8.

URL: https://www.ncbi.nlm.nih.gov/pubmed/18187653
DOI: 10.1126/science.1150224


Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)-derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.

Item Type: Paper
Additional Information:
Subjects: diseases & disorders > cancer
organism description > animal > mammal > rodent > mouse
diseases & disorders > pulmonary disease
CSHL Authors:
Communities: CSHL labs > Mittal lab
Depositing User: Tom Adams
Date: 11 January 2008
Date Deposited: 12 Jul 2011 15:14
Last Modified: 14 Mar 2018 16:42
Related URLs:
URI: https://repository.cshl.edu/id/eprint/7740

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