Adult neurogenesis, mental health, and mental illness: hope or hype?

Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G. L., Overstreet-Wadiche, L. S. (2008) Adult neurogenesis, mental health, and mental illness: hope or hype? J Neurosci, 28 (46). pp. 11785-91.

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DOI: 10.1523/JNEUROSCI.3798-08.2008


Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Research suggests that regulation of adult hippocampal neurogenesis represents a promising approach to treating and perhaps preventing mental illness. Here we appraise the role of adult hippocampal neurogenesis in major psychiatric and neurologic disorders within the essential framework of recent progress made in understanding "normal" adult neurogenesis. Topics addressed include the following: the life cycle of an adult hippocampal stem cell and the implications for aging; links between learning and hippocampal neurogenesis; the reciprocal relationship between cocaine self-administration and adult hippocampal neurogenesis; the role of adult neurogenesis in an animal model of depression and response to antidepressant exposure; the impact of neonatal seizures on dentate gyrus neurogenesis; and the contribution of a schizophrenia-susceptibility gene to adult hippocampal neurogenesis. These topics are discussed in light of the regulation of adult neurogenesis, the relationship to normal neurogenesis in adulthood and aging, and, importantly, the manipulation of neurogenesis to promote mental health and treat mental illness.

Item Type: Paper
Uncontrolled Keywords: neural stem cell epilepsy learning depression addiction schizophrenia
Subjects: bioinformatics
diseases & disorders > mental disorders
diseases & disorders > nervous system diseases and disorders
diseases & disorders > mental disorders > schizophrenia
diseases & disorders > mental disorders > substance related disorders
organism description > animal > developmental stage > adult
organism description > animal > mammal > primates > hominids > human
CSHL Authors:
Communities: CSHL labs > Enikopolov lab
Depositing User: Tom Adams
Date: 2008
Date Deposited: 25 Aug 2011 15:21
Last Modified: 13 Mar 2018 20:46
PMCID: PMC2793333
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