Liu, Ying, Janowitz, Tobias (October 2026) Activity over Abundance: ADAMTSL4 Unlocks Latent TGFβ1 in Cancer Cachexia. Cancer Discovery, 16 (10). pp. 1964-1966. ISSN 2159-8274
Abstract
Cancer cachexia is increasingly recognized as a coordinated, tumor-induced, unsustainable alteration in interorgan communication. Machado and colleagues identify a new molecular mechanism that promotes cachexia, in which tumor-secreted ADAMTSL4 drives tissue wasting by promoting local activation of latent TGFβ1, revealing post-secretory control of ligand activation as a potential therapeutic vulnerability in cancer cachexia. See related article by Machado et al., p. 2172.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders diseases & disorders > neoplasms diseases & disorders > nutritional and metabolic diseases diseases & disorders > nutritional and metabolic diseases > cachexia |
| CSHL Authors: | |
| Communities: | CSHL labs > Janowitz lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 1 October 2026 |
| Date Deposited: | 02 Oct 2026 15:35 |
| Last Modified: | 02 Oct 2026 15:35 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42330 |
Actions (login required)
 |
Administrator's edit/view item |