Therapeutic Innovations for Monkeypox Inhibition

De, Nayan, Bhadra, Jhuma, Momin, Md Sorique Aziz, Mitra, Kamala, Bhunia, Debmalya, Sannigrahi, Achinta (May 2026) Therapeutic Innovations for Monkeypox Inhibition. International Journal of Molecular Sciences, 27 (10). p. 4307. ISSN 1661-6596

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Abstract

This review investigates biomaterial-based strategies for improved treatment of MPXV. We focus on emerging synthetic biomedical approaches to combating the virus. These include peptide nucleic acids, CRISPR-based systems, and small-molecule therapeutics. These methods work by targeting and blocking viral proteins and enzymes. Such synthetic platforms may help reduce viral transmission and minimize side effects. They also offer potential solutions to challenges such as viral resistance in humans. In addition, biomaterials contribute to the development of more stable and effective vaccines. Combining these biomaterials with mRNA technology provides a promising framework for future vaccine development. Overall, this review underscores biomaterial-driven antiviral systems as a major frontier in translational medicine with profound implications for global health and pandemic awareness.

Item Type:	Paper
CSHL Authors:	Bhunia, Debmalya
Communities:	CSHL labs > Wigler lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	12 May 2026
Date Deposited:	29 Jun 2026 13:21
Last Modified:	29 Jun 2026 13:21
PMCID:	PMC13206911
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/42239

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