Zhang, Yuqing, Nipp, Ryan D, Janowitz, Tobias, Li, Yi-Ping, Guttridge, Denis C, Li, Min (April 2026) Cancer cachexia: A tumor-driven disorder of whole-body homeostasis. Cancer Cell. S1535-6108(26)00166. ISSN 1535-6108
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Abstract
Cancer cachexia is a systemic metabolic syndrome driven by tumor-induced disruption of whole-body homeostasis. Characterized by skeletal muscle atrophy and adipose tissue loss, cachexia leads to functional decline, impaired quality of life, reduced treatment tolerance, and poor survival across multiple malignancies. Emerging evidence indicates that cachexia arises from complex and dynamic interactions between tumors and host organ systems, including immune, metabolic, endocrine, and neural networks, that collectively reshape energy balance, immune function, and tissue integrity. Despite its profound clinical impact, effective therapies remain limited, reflecting incomplete mechanistic understanding and the absence of integrated clinical frameworks. Here, we review recent advances in cachexia biology, including tumor-host signaling, multiorgan metabolic remodeling, and neuroendocrine regulation. We further propose a tumor-centric framework in which cachexia represents a progressive collapse of systemic homeostasis and outline translational strategies to guide mechanism-informed therapeutic interventions.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders diseases & disorders > nutritional and metabolic diseases diseases & disorders > nutritional and metabolic diseases > cachexia |
| CSHL Authors: | |
| Communities: | CSHL labs > Janowitz lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 16 April 2026 |
| Date Deposited: | 12 May 2026 14:46 |
| Last Modified: | 12 May 2026 14:46 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42203 |
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