Lee, Hayan, Gurtowski, James, Yoo, Shinjae, Nattestad, Maria, Marcus, Shoshana, Goodwin, Sara, Richard McCombie, W, Schatz, Michael C (April 2016) Third-generation sequencing and the future of genomics. bioRxiv. ISSN 2692-8205 (Submitted)
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Abstract
Third-generation long-range DNA sequencing and mapping technologies are creating a renaissance in high-quality genome sequencing. Unlike second-generation sequencing, which produces short reads a few hundred base-pairs long, third-generation single-molecule technologies generate over 10,000 bp reads or map over 100,000 bp molecules. We analyze how increased read lengths can be used to address longstanding problems in de novo genome assembly, structural variation analysis and haplotype phasing.
| Item Type: | Paper |
|---|---|
| Subjects: | Investigative techniques and equipment Investigative techniques and equipment > assays |
| CSHL Authors: | |
| Communities: | CSHL labs > McCombie lab CSHL labs > Schatz lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 13 April 2016 |
| Date Deposited: | 24 Mar 2026 18:49 |
| Last Modified: | 24 Mar 2026 18:49 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42112 |
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