Sun, Simón ED, Tollkuhn, Jessica (March 2026) Sex Hormone Control of Neurophysiology and Behavior. Annual Review of Neuroscience. ISSN 0147-006X
Abstract
Sex hormones are a primary source for biological variation throughout the animal kingdom, from morphological characteristics to elaborate courtship displays. These steroids, such as estrogens and androgens, are indispensable for the development and function of the nervous tissues that mediate sex differences in reproduction, metabolism, and social behavior. Crucially, the cognate receptors for sex hormones are transcription factors that bind DNA to regulate expression of nearby genes. Although there has been substantial recent progress in dissecting the neural circuitry that regulates sex-differential behaviors, there is a dearth of understanding regarding how sex hormones act on this circuitry to modulate behavior. Here, we focus on the transcriptional actions of sex hormone receptors and the functions of their target genes, particularly voltage-gated ion channels. We put forth a framework in which sex hormone receptor modulation of gene expression affects cell activity states across interconnected brain regions, leading to emergent social behaviors.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > hormones bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types |
| CSHL Authors: | |
| Communities: | CSHL labs > Tollkuhn lab CSHL Post Doctoral Fellows |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 20 March 2026 |
| Date Deposited: | 23 Mar 2026 12:33 |
| Last Modified: | 23 Mar 2026 12:37 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42105 |
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