Wu, Y, Borniger, JC (July 2023) Systemic interactions between cancer and the nervous system. In: Cancer Neuroscience. UNSPECIFIED, pp. 147-168. ISBN 9783031324284
Abstract
Nervous systems were not classically considered to be actively involved in the process of tumorigenesis and cancer metastasis. However, studies over the last decade have demonstrated the presence of neurons and glial cells in the peritumoral regions of many human tumors, and the density of tumor-associated nerves is often correlated with cancer progression and metastatic spread. In general, it has been demonstrated that neuronal activity is widely pro-cancer in the brain, and blocking neural activity usually confers anticancer benefits [1]. For example, increased neuronal excitability has been observed in preclinical models of both pediatric and adult gliomas [2-4], and nerve ablation can suppress tumor development in various other malignancies [5]. With the growing global cancer burden, research in the nascent field of cancer neuroscience is quickly becoming intense, attracting interdisciplinary efforts from all over the world. This chapter will focus on the reciprocal cross talk between cancer and the nervous system via direct and indirect pathways. Subsequent influences on host behavior and cancer therapeutic resistance will also be discussed.
| Item Type: | Book Section |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders neurobiology neurobiology > neuroscience |
| CSHL Authors: | |
| Communities: | CSHL labs > Borniger lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 25 July 2023 |
| Date Deposited: | 17 Feb 2026 15:09 |
| Last Modified: | 18 Feb 2026 13:45 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42090 |
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