Sebé-Pedrós, Arnau, Tanay, Amos, Lawniczak, Mara KN, Arendt, Detlev, Aerts, Stein, Archibald, John, Arnone, Maria Ina, Blaxter, Mark, Cleves, Phillip, Coelho, Susana M, Dias, Mafalda, Dunn, Casey, Elek, Anamaria, Frazer, Jonathan, Gabaldón, Toni, Gillis, Jesse, Grau-Bové, Xavier, Guigó, Roderic, Hobert, Oliver, Huerta-Cepas, Jaime, Irimia, Manuel, Klein, Allon, Lewin, Harris, Lowe, Christopher J, Marlow, Heather, Musser, Jacob M, Nagy, László G, Najle, Sebastián R, Pachter, Lior, Paez, Sadye, Papatheodorou, Irene, Passalacqua, Michael J, Rajewsky, Nikolaus, Rhee, Seung Y, Richards, Thomas A, Sauka-Spengler, Tatjana, Saunders, Lauren M, Seuntjens, Eve, Solana, Jordi, Song, Yuyao, Technau, Ulrich, Wang, Bo, Biodiversity Cell Atlas meeting participants (September 2025) The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution. Nature, 645 (8082). pp. 877-885. ISSN 0028-0836
Abstract
Cell types are fundamental functional units that can be traced across the tree of life. Rapid advances in single-cell technologies, coupled with the phylogenetic expansion in genome sequencing, present opportunities for the molecular characterization of cells across a broad range of organisms. Despite these developments, our understanding of eukaryotic cell diversity remains limited and we are far from decoding this diversity from genome sequences. Here we introduce the Biodiversity Cell Atlas initiative, which aims to create comprehensive single-cell molecular atlases across the eukaryotic tree of life. This community effort will be phylogenetically informed, rely on high-quality genomes and use shared standards to facilitate comparisons across species. The Biodiversity Cell Atlas aspires to deepen our understanding of the evolution and diversity of life at the cellular level, encompassing gene regulatory programs, differentiation trajectories, cell-type-specific molecular profiles and inter-organismal interactions.
| Item Type: | Paper |
|---|---|
| CSHL Authors: | |
| Communities: | CSHL labs > Gillis Lab School of Biological Sciences > Publications |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | September 2025 |
| Date Deposited: | 06 Jan 2026 14:23 |
| Last Modified: | 06 Jan 2026 14:23 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/42061 |
Actions (login required)
 |
Administrator's edit/view item |