Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration

Murray, ME, Smith, C, Menon, V, Keene, CD, Lein, E, Hawrylycz, M, Aguzzi, A, Benedetti, B, Brose, K, Caetano-Anolles, K, Sillero, MIC, Crary, JF, De Jager, PL, Faustin, A, Flanagan, ME, Gokce, O, Grant, SGN, Grinberg, LT, Gutman, DA, Hillman, EMC, Huang, Z, Irwin, DJ, Jones, DT, Kapasi, A, Karch, CM, Kukull, WT, Lashley, T, Lee, EB, Lehner, T, Parkkinen, L, Pedersen, M, Pritchett, D, Rutledge, MH, Schneider, JA, Seeley, WW, Shepherd, CE, Spires-Jones, TL, Steen, JA, Sutherland, M, Vickovic, S, Zhang, B, Stewart, DJ, Keiser, MJ, Vogel, JW, Dugger, BN, Phatnani, H (July 2025) Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration. Neuron. ISSN 0896-6273

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Abstract

Transformative neuropathology is redefining human brain research by integrating foundational descriptive pathology with advanced methodologies. These approaches, spanning multi-omics studies and machine learning applications, will drive discovery for the identification of biomarkers, therapeutic targets, and complex disease patterns through comprehensive analyses of postmortem human brain tissue. Yet critical challenges remain, including the sustainability of brain banks, expanding donor participation, strengthening training pipelines, enabling rapid autopsies, supporting collaborative platforms, and integrating data across modalities. Innovations in digital pathology, tissue quality enhancement, harmonization of data standards, and machine learning integration offer opportunities to accelerate tissue-level “pathomics” research in brain health through cross-disciplinary collaborations. Lessons from neuroimaging, particularly in establishing common data frameworks and multi-site collaborations, offer a valuable roadmap for streamlining innovations. In this perspective, we outline actionable solutions for leveraging existing resources and strengthening collaboration -where we envision future opportunities to drive translational discoveries stemming from transformative neuropathology.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions
CSHL Authors:	Stewart, David
Communities:	Meetings and Courses
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	18 July 2025
Date Deposited:	01 Oct 2025 14:54
Last Modified:	01 Oct 2025 14:54
PMCID:	PMC12313173
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41974

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