Boyd, Leah, Borniger, Jeremy C (August 2025) Tumor-derived small extracellular vesicles reprogram sensory nerves to drive immunosuppression in the tumor microenvironment. Science Signaling, 18 (898). ISSN 1945-0877
Abstract
Neuroimmune cross-talk is emerging as an important regulator of tumor growth and progression in cancers beyond the central nervous system. In this issue of Science Signaling, Restaino et al. demonstrate that tumor-derived small extracellular vesicles promote tumor growth by altering the secretory profile of infiltrating sensory neurons, generating a feed-forward loop that ultimately drives immunosuppression in the tumor microenvironment.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders diseases & disorders > neoplasms |
| CSHL Authors: | |
| Communities: | CSHL labs > Borniger lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 5 August 2025 |
| Date Deposited: | 07 Aug 2025 11:59 |
| Last Modified: | 07 Aug 2025 12:00 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41927 |
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