Cancer mortality and senescence: Is redox therapy an option?

Kuang, Shan, Swamynathan, Manojit M, Trotman, Lloyd C (July 2025) Cancer mortality and senescence: Is redox therapy an option? Genes & Development. ISSN 0890-9369

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Abstract

Patient genomics and mouse functional genetics have revealed that senescence is a barrier to metastatic progression of prostate cancer. Many efforts focus on eliminating senescent cells, whereas others aim to elucidate distinct characteristics that set them apart from normal and aging cells. Here, we discuss how exploration of the redox state of senescent cells could help define new markers and pro-oxidant vulnerabilities, drawing analogy to what is known about the redox sensitivity of proliferating cancer cells.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence
CSHL Authors:	Trotman, Lloyd C. Kuang, Shan Swamynathan, Manojit Mosur
Communities:	CSHL labs > Trotman lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	14 July 2025
Date Deposited:	15 Jul 2025 14:06
Last Modified:	15 Jul 2025 14:06
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41908

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