Aging and immunity: the age-old tango

Fernández Maestre, Inés, Harris, Alexander S, Amor, Corina (May 2025) Aging and immunity: the age-old tango. Genes & Development. ISSN 0890-9369

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Abstract

The rising global demographic aging and the subsequent increase in the prevalence of age-related diseases highlight the need to understand aging biology. A key player in organismal aging is the immune system, which has broad systemic effects. On the one hand, immune aging involves the decline of hematopoietic stem cells and significant alterations in the functionality and composition of both innate and adaptive immunity. On the other hand, the aged immune system contributes to chronic inflammation and disrupted tissue homeostasis, thereby driving systemic aging processes. In this review, we examine the close interaction between aging and the immune system and discuss emerging therapeutic strategies aimed at modulating immune function to mitigate age-related pathologies.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > senescence
CSHL Authors:	Amor, Corina Harris, Alexander
Communities:	CSHL Post Doctoral Fellows CSHL labs > Amor lab CSHL Cancer Center Program CSHL Cancer Center Program > Cellular Communication in Cancer Program
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	28 May 2025
Date Deposited:	18 Jun 2025 14:00
Last Modified:	10 Aug 2026 15:15
PMCID:	PMC12315898
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41894

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