Asynchronous development of the mouse auditory cortex is driven by hemispheric identity and sex

Reid, Ashlan P, Neophytou, Demetrios, Levy, Robert, Pham, Cody, Oviedo, Hysell V (April 2025) Asynchronous development of the mouse auditory cortex is driven by hemispheric identity and sex. Nature Communications, 16 (1). p. 3654. ISSN 2041-1723

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Abstract

Lateralized auditory processing is essential for specialized functions such as speech processing, typically dominated by the Left Auditory Cortex (ACx) in humans. Hemispheric specializations also occur in the adult mouse ACx, but their developmental origins are unclear. Our study finds that the Left and Right ACx in mice reach developmental milestones at different ages. Thalamocortical responses and maturation of synaptic dynamics develop earlier in the Right ACx than the Left. We show that this timing offset predicts hemisphere-dependent differences in sensory-driven plasticity. Juvenile tone exposure at specific times results in imbalanced adult tone frequency representations in the Right and Left ACx. Additionally, sex influences the timing of plasticity; female Right ACx plasticity occurs before male Right ACx, and female Left ACx aligns with male Right ACx plasticity. Our findings demonstrate that sex and hemispheric identity drive asynchronous development and contribute to functional differences in sensory cortices.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Reid, Ashlan
Communities:	CSHL labs > Zador lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	17 April 2025
Date Deposited:	17 Jun 2025 17:51
Last Modified:	17 Jun 2025 17:51
PMCID:	PMC12006290
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41893

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