Identification of B cell antigens in solid cancer: initial insights and functional implications

Yang, Jung-In, Moresco, Philip, Fearon, Douglas, Yao, Min (April 2025) Identification of B cell antigens in solid cancer: initial insights and functional implications. Frontiers in Immunology, 16. p. 1571570. ISSN 1664-3224

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Abstract

Cancer antigen discovery has mostly focused on T cell antigens, while antigens driving B cell responses have been largely overlooked despite representing another important branch of adaptive immune responses in cancer. Traditional B cell antigens in cancer have been studied using serological approaches analyzing polyclonal antibodies in serum. With recent technological advances in single-cell sequencing, a few studies have begun to investigate single B cell antigen specificity in the tumor microenvironment using immunoglobulin single-cell sequencing, recombinant monoclonal antibody production, cancer binding screening, and antigen identification. In this review, we highlight the initial insights into B cell directed cancer antigens and categorize them into cancer-associated viral antigens and non-viral antigens, with the latter featuring autoantigens. We will further discuss the functions of B cells in cancer in the context of their antigen specificity, and categorize their functions into antibody effector function, T cell activation, and B cell secretion. Lastly, we will provide perspectives on the challenges and opportunities in the identification of new B cell cancer antigens and highlight their translational potential.

Item Type:	Paper
Subjects:	diseases & disorders diseases & disorders > neoplasms
CSHL Authors:	Yang, Jung-In Moresco, Philip Fearon, Douglas
Communities:	CSHL labs > Fearon lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	28 April 2025
Date Deposited:	14 May 2025 19:55
Last Modified:	14 May 2025 19:55
PMCID:	PMC12066463
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41875

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