Buchanan, JoAnn, Cheadle, Lucas (April 2025) The Many Lives of an Oligodendrocyte Precursor Cell. Annual Review of Neuroscience. ISSN 0147-006X
Abstract
Oligodendrocyte precursor cells (OPCs) are glia that give rise to myelinating oligodendrocytes in the developing and adult brain. However, emerging data suggest that OPCs perform a wide range of functions beyond oligodendrogenesis. For example, OPCs receive direct synaptic input from neurons, and they respond to neural activity through the release of factors that alter neuronal function. Moreover, OPCs directly associate with the neurovasculature to promote blood-brain barrier maintenance and integrity. Emerging data suggest that OPCs can refine synaptic connectivity during brain development, a process to which they contribute by phagocytosing synapses. Finally, OPCs are also involved in brain immunity, as they can adopt immune cell-like functions during demyelinating and neurodegenerative diseases. Altogether, these findings have identified OPCs as the major multitaskers of the brain. In this review, we discuss the roles of OPCs that extend beyond oligodendrocyte production and their relevance for neurological function.
| Item Type: | Paper |
|---|---|
| Subjects: | neurobiology neurobiology > neuroscience |
| CSHL Authors: | |
| Communities: | CSHL labs > Cheadle lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 15 April 2025 |
| Date Deposited: | 21 Apr 2025 12:44 |
| Last Modified: | 21 Apr 2025 12:44 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41854 |
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