Lewis, Steven M, Dos Santos, Camila (November 2024) Epigenetic scars of Brca1 loss point toward breast cancer cell of origin. Nature Genetics. ISSN 1061-4036
Abstract
The two-hit hypothesis suggests that a second mutation is necessary for cancer development in cells with a defective tumor-suppressor gene, such as BRCA1. However, a study now shows that the loss of just one Brca1 allele in mice can pre-program cells for cancer-promoting changes, indicating cancer may progress earlier than previously thought.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders diseases & disorders > cancer > cancer types > breast cancer diseases & disorders > cancer > cancer types |
| CSHL Authors: | |
| Communities: | CSHL Cancer Center Program > Cancer Genetics and Genomics Program CSHL labs > Dos Santos lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 20 November 2024 |
| Date Deposited: | 21 Nov 2024 13:48 |
| Last Modified: | 21 Nov 2024 13:48 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41737 |
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