Faust, Travis E, Devlin, Benjamin A, Farhy-Tselnicker, Isabella, Ferro, Austin, Postolache, Maggie, Xin, Wendy (October 2024) Glial Control of Cortical Neuronal Circuit Maturation and Plasticity. Journal of Neuroscience, 44 (40). e1208242024-e1208242024. ISSN 0270-6474
Abstract
The brain is a highly adaptable organ that is molded by experience throughout life. Although the field of neuroscience has historically focused on intrinsic neuronal mechanisms of plasticity, there is growing evidence that multiple glial populations regulate the timing and extent of neuronal plasticity, particularly over the course of development. This review highlights recent discoveries on the role of glial cells in the establishment of cortical circuits and the regulation of experience-dependent neuronal plasticity during critical periods of neurodevelopment. These studies provide strong evidence that neuronal circuit maturation and plasticity are non-cell autonomous processes that require both glial-neuronal and glial-glial cross talk to proceed. We conclude by discussing open questions that will continue to guide research in this nascent field.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Cheadle lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 2 October 2024 |
| Date Deposited: | 07 Oct 2024 13:53 |
| Last Modified: | 07 Oct 2024 13:53 |
| PMCID: | PMC11450532 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41698 |
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