Borniger, Jeremy C (October 2024) Cancer neuroscience at the brain-body interface. Genes & Development. ISSN 0890-9369
Abstract
Our approaches toward understanding cancer have evolved beyond cell-intrinsic and local microenvironmental changes within the tumor to encompass how the cancer interfaces with the entire host organism. The nervous system is uniquely situated at the interface between the brain and body, constantly receiving and sending signals back and forth to maintain homeostasis and respond to salient stimuli. It is becoming clear that various cancers disrupt this dialog between the brain and body via both neuronal and humoral routes, leading to aberrant brain activity and accelerated disease. In this outlook, I discuss this view of cancer as a homeostatic challenge, emphasize cutting-edge work, and provide outstanding questions that need to be answered to move the field forward.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders neurobiology neurobiology > neuroscience |
| CSHL Authors: | |
| Communities: | CSHL labs > Borniger lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 3 October 2024 |
| Date Deposited: | 07 Oct 2024 13:19 |
| Last Modified: | 20 Nov 2024 16:06 |
| PMCID: | PMC11535155 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41696 |
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