New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them

Wu, B, Koehler, AN, Westcott, PMK (September 2024) New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them. Trends in Biochemical Sciences. ISSN 0968-0004

URL: https://pubmed.ncbi.nlm.nih.gov/39277450/

DOI: 10.1016/j.tibs.2024.08.002

Abstract

Immune checkpoint blockade (ICB) therapies, which block inhibitory receptors on T cells, can be efficacious in reinvigorating dysfunctional T cell responses. However, most cancers do not respond to these therapies and even in those that respond, tumors can acquire resistance. New strategies are needed to rescue and recruit T cell responses across patient populations and disease states. In this review, we define mechanisms of T cell dysfunction, focusing on key transcription factor (TF) networks. We discuss the complex and sometimes contradictory roles of core TFs in both T cell function and dysfunction. Finally, we review strategies to target TFs using small molecule modulators, which represent a challenging but highly promising opportunity to tune the T cell response toward sustained immunity.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions
CSHL Authors:	Westcott, Peter
Communities:	CSHL Cancer Center Program > Cancer Genetics and Genomics Program CSHL Cancer Center Program CSHL labs > Westcott lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	13 September 2024
Date Deposited:	23 Sep 2024 14:03
Last Modified:	23 Sep 2024 14:03
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41684

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