Wu, B, Koehler, AN, Westcott, PMK
(September 2024)
New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them.
Trends in Biochemical Sciences.
ISSN 0968-0004
Abstract
Immune checkpoint blockade (ICB) therapies, which block inhibitory receptors on T cells, can be efficacious in reinvigorating dysfunctional T cell responses. However, most cancers do not respond to these therapies and even in those that respond, tumors can acquire resistance. New strategies are needed to rescue and recruit T cell responses across patient populations and disease states. In this review, we define mechanisms of T cell dysfunction, focusing on key transcription factor (TF) networks. We discuss the complex and sometimes contradictory roles of core TFs in both T cell function and dysfunction. Finally, we review strategies to target TFs using small molecule modulators, which represent a challenging but highly promising opportunity to tune the T cell response toward sustained immunity.
Item Type: |
Paper
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Subjects: |
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > T cells organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions |
CSHL Authors: |
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Communities: |
CSHL Cancer Center Program > Cancer Genetics and Genomics Program CSHL Cancer Center Program CSHL labs > Westcott lab |
SWORD Depositor: |
CSHL Elements
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Depositing User: |
CSHL Elements
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Date: |
13 September 2024 |
Date Deposited: |
23 Sep 2024 14:03 |
Last Modified: |
23 Sep 2024 14:03 |
Related URLs: |
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URI: |
https://repository.cshl.edu/id/eprint/41684 |
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