Establishing a biochemical understanding of the initiation of chromosome replication in bacteria

Stillman, Bruce (June 2024) Establishing a biochemical understanding of the initiation of chromosome replication in bacteria. Proceedings of the National Academy of Sciences of the United States of America, 121 (23). e2400667121. ISSN 0027-8424

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URL: https://www.ncbi.nlm.nih.gov/pubmed/38758693
DOI: 10.1073/pnas.2400667121

Abstract

In the mid-1950s, Arthur Kornberg elucidated the enzymatic synthesis of DNA by DNA polymerase, for which he was recognized with the 1959 Nobel Prize in Physiology or Medicine. He then identified many of the proteins that cooperate with DNA polymerase to replicate duplex DNA of small bacteriophages. However, one major unanswered problem was understanding the mechanism and control of the initiation of chromosome replication in bacteria. In a seminal paper in 1981, Fuller, Kaguni, and Kornberg reported the development of a cell-free enzyme system that could replicate DNA that was dependent on the bacterial origin of DNA replication, oriC. This advance opened the door to a flurry of discoveries and important papers that elucidated the process and control of initiation of chromosome replication in bacteria.

Item Type: Paper
Subjects: bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > DNA polymerase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organism description > bacteria
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
CSHL Authors:
Communities: CSHL labs > Stillman lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 4 June 2024
Date Deposited: 20 May 2024 12:50
Last Modified: 20 May 2024 12:50
Related URLs:
URI: https://repository.cshl.edu/id/eprint/41550

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