Klindt, David (2021) Modelling Functional Wiring and Processing from Retinal Bipolar to Ganglion Cells. In: Cosyne Conference, 2021.
Abstract
Although the processing of visual information in the retina has been studied in detail, the underlying functional connectivity is not yet completely understood. While many specific circuits are well-characterized (e.g. the rod photoreceptor pathway), a comprehensive picture of how these microcircuits work together to form the retinal network is still lacking. Furthermore, connectomic information, which could help dissect the functional underpinnings of the retina, is not yet fully leveraged. The integration of different datasets and data sources to (computational) models is a key challenge to elucidate the processing of visual information in the retina. A step towards a comprehensive understanding of the retinal network was made in a recent publication [1], which suggests a biophysically-constrained bipolar and amacrine cell network model (BCN model) of light processing in the mouse inner retina, enabling in silico experiments. Here, we extended this model to predict the responses of previously characterized mouse retinal ganglion cell (RGC) types to full-field light stimulation [2]. Specifically, we tested how bipolar cell glutamate release can be combined in an additional linear nonlinear model to predict RGC output (BCN-LN). We show that recordings of full-field stimulation combined with mechanistically detailed modelling allowed us to predict connectivity between cell types, as well as to investigate the role of inhibitory feedback and feedforward AC modulation. In summary, this work shows how a machine-learning approach informed by biological structures can produce interpretable and accurate predictions about neural connectivity and circuit functions, thus explaining the hierarchical emergence of functional RGC diversity.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > retina organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Klindt lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 2021 |
| Date Deposited: | 11 Apr 2024 15:51 |
| Last Modified: | 11 Apr 2024 15:51 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41500 |
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