Stable sound decoding despite modulated sound representation in the auditory cortex

Funamizu, Akihiro, Marbach, Fred, Zador, Anthony M (September 2023) Stable sound decoding despite modulated sound representation in the auditory cortex. bioRxiv. (Submitted)

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Abstract

The activity of neurons in the auditory cortex is driven by both sounds and non-sensory context. To investigate the neuronal correlates of non-sensory context, we trained head-fixed mice to perform a two-alternative choice auditory task in which either reward or stimulus expectation (prior) was manipulated in blocks. Using two-photon calcium imaging to record populations of single neurons in auditory cortex, we found that both stimulus and reward expectation modulated the activity of these neurons. A linear decoder trained on this population activity could decode stimuli as well or better than predicted by the animal's performance. Interestingly, the optimal decoder was stable even in the face of variable sensory representations. Neither the context nor the mouse's choice could be reliably decoded from the recorded neural activity. Our findings suggest that in spite of modulation of auditory cortical activity by task priors, auditory cortex does not represent sufficient information about these priors to exploit them optimally and that decisions in this task require that rapidly changing sensory information be combined with more slowly varying task information extracted and represented in brain regions other than auditory cortex.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Marbach, Fred Zador, Anthony M. Funamizu, Akihiro
Communities:	CSHL labs > Zador lab School of Biological Sciences > Publications
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	15 September 2023
Date Deposited:	23 Feb 2024 16:00
Last Modified:	29 Feb 2024 21:12
PMCID:	PMC10515783
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41442

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