Werner, Jonathan M, Hover, John, Gillis, Jesse (October 2023) Population variability in X-chromosome inactivation across 9 mammalian species. (Submitted)
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Abstract
One of the two X chromosomes in female mammals is epigenetically silenced in embryonic stem cells by X chromosome inactivation (XCI). This creates a mosaic of cells expressing either the maternal or the paternal X allele. The XCI ratio, the proportion of inactivated parental alleles, varies widely among individuals, representing the largest instance of epigenetic variability within mammalian populations. While various contributing factors to XCI variability are recognized, namely stochastic and/or genetic effects, their relative contributions are poorly understood. This is due in part to limited cross-species analysis, making it difficult to distinguish between generalizable or species-specific mechanisms for XCI ratio variability. To address this gap, we measured XCI ratios in nine mammalian species (9,143 individual samples), ranging from rodents to primates, and compared the strength of stochastic models or genetic factors for explaining XCI variability. Our results demonstrate the embryonic stochasticity of XCI is a general explanatory model for population XCI variability in mammals, while genetic factors play a minor role.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics organism description > animal organism description > animal > mammal bioinformatics > genomics and proteomics > genetics & nucleic acid processing > population genetics |
| CSHL Authors: | |
| Communities: | CSHL labs > Gillis Lab CSHL labs > Zador lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 19 October 2023 |
| Date Deposited: | 08 Nov 2023 13:26 |
| Last Modified: | 08 Nov 2023 13:26 |
| PMCID: | PMC10614859 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41304 |
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