Grange, Pascal, Hawrylycz, Michael, Mitra, Partha P (January 2013) Computational neuroanatomy and co-expression of genes in the adult mouse brain, analysis tools for the Allen Brain Atlas. (Submitted)
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Abstract
We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of the distribution of co-expression networks of a given size. We apply them to the Allen Atlas of the adult mouse brain, and to the co-expression network of a set of genes related to nicotine addiction retrieved from the NicSNP database. The computational methods are implemented in BrainGeneExpressionAnalysis, a Matlab toolbox available for download.
| Item Type: | Paper |
|---|---|
| Subjects: | Investigative techniques and equipment > brain atlas organism description > animal > mammal > rodent > mouse neurobiology > neuroanatomy |
| CSHL Authors: | |
| Communities: | CSHL labs > Mitra lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 8 January 2013 |
| Date Deposited: | 13 Oct 2023 15:37 |
| Last Modified: | 13 Oct 2023 15:37 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41244 |
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