The state of hepatic artery infusion chemotherapy in the management of metastatic colorectal cancer to the liver

Leung, Marcia, Gholami, Sepideh (October 2019) The state of hepatic artery infusion chemotherapy in the management of metastatic colorectal cancer to the liver. Chinese clinical oncology, 8 (5). p. 54. ISSN 2304-3865

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Abstract

Hepatic artery infusion (HAI) chemotherapy is a locoregional therapy for colorectal cancer liver metastasis that has been available since the 1980s. Multiple clinical trials have demonstrated the safety and efficacy of HAI with higher response rates compared to systemic chemotherapy alone. Clinical trials have shown the benefit of using HAI as a bridge to conversion to resection at a higher rate than systemic chemotherapy alone with rates as high as 60% in heavily pretreated patients. HAI in combination with systemic chemotherapy has also been associated with prolonged recurrence free survival and overall survival in the adjuvant setting. Specifically, the addition of HAI continues to show a benefit in prolonging overall survival, despite increased effectiveness of modern systemic chemotherapy (i.e., oxaliplatin and irinotecan). Lower recurrence and improved survival rates associated with HAI and systemic chemotherapy persist regardless of RAS mutational status.

Item Type:	Paper
Subjects:	diseases & disorders Investigative techniques and equipment diseases & disorders > neoplasms Investigative techniques and equipment > biomarker diseases & disorders > cancer > cancer types > colon cancer diseases & disorders > cancer > cancer types > colon cancer organs, tissues, organelles, cell types and functions > organs types and functions > liver diseases & disorders > cancer > metastasis
CSHL Authors:	Gholami, Sepideh
Communities:	CSHL labs > Gholami Lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	October 2019
Date Deposited:	05 Oct 2023 20:14
Last Modified:	02 Feb 2024 16:45
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41161

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