Lou, Emil, Gholami, Sepideh, Romin, Yevgeniy, Thayanithy, Venugopal, Fujisawa, Sho, Desir, Snider, Steer, Clifford J, Subramanian, Subbaya, Fong, Yuman, Manova-Todorova, Katia, Moore, Malcolm AS (October 2017) Imaging Tunneling Membrane Tubes Elucidates Cell Communication in Tumors. Trends in Cancer, 3 (10). pp. 678-685. ISSN 2405-8033
Abstract
Intercellular communication is a vital yet underdeveloped aspect of cancer pathobiology. This Opinion article reviews the importance and challenges of microscopic imaging of tunneling nanotubes (TNTs) in the complex tumor microenvironment. The use of advanced microscopy to characterize TNTs in vitro and ex vivo, and related extensions called tumor microtubes (TMs) reported in gliomas in vivo, has propelled this field forward. This topic is important because the identification of TNTs and TMs fills the gap in our knowledge of how cancer cells communicate at long range in vivo, inducing intratumor heterogeneity and resistance to treatment. Here we discuss the concept that TNTs/TMs fill an important niche in the ever-changing microenvironment and the role of advanced microscopic imaging to elucidate that niche.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders > neoplasms |
| CSHL Authors: | |
| Communities: | CSHL labs > Gholami Lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | October 2017 |
| Date Deposited: | 05 Oct 2023 19:53 |
| Last Modified: | 05 Oct 2023 19:53 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41155 |
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