Au, Joyce T, Kingham, T Peter, Jun, Kyonghwa, Haddad, Dana, Gholami, Sepideh, Mojica, Kelly, Monette, Sebastien, Ezell, Paula, Fong, Yuman (June 2013) Irreversible electroporation ablation of the liver can be detected with ultrasound B-mode and elastography. Surgery, 153 (6). pp. 787-793. ISSN 0039-6060
Abstract
BACKGROUND: Irreversible electroporation (IRE) is a novel ablation technique that induces permanent membrane permeability and cell death. We are interested in ultrasound B-mode and elastography to monitor IRE ablation in the liver. METHODS: Yorkshire pigs underwent IRE ablation of the liver and were imaged with ultrasound B-mode and elastography. Histologic evaluation of cell death by triphenyltetrazolium chloride and hematoxylin and eosin staining was performed. RESULTS: Elastography showed that liver ablated by IRE exhibited increased tissue stiffness with a peak strain ratio of 2.22. The IRE lesion had a discrete border without bubble artifact, and the lesion size significantly correlated with area of cell death on histology. IRE ablation was unaffected by presence of large blood vessels or bile ducts. CONCLUSION: IRE ablation led to increased tissue stiffness that was detectable by elastography and indicative of cell death. Elastography may complement B-mode ultrasonography to monitor IRE ablation of the liver.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > organs types and functions > liver |
| CSHL Authors: | |
| Communities: | CSHL labs > Gholami Lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | June 2013 |
| Date Deposited: | 05 Oct 2023 18:33 |
| Last Modified: | 05 Oct 2023 18:33 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41142 |
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