Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal

Trejo, Diego Hernandez, Ciuparu, Andrei, da Silva, Pedro Garcia, Velasquez, Cristina M, Rebouillat, Benjamin, Gross, Michael D, Davis, Martin B, Muresan, Raul C, Albeanu, Dinu F (September 2023) Fast updating feedback from piriform cortex to the olfactory bulb relays multimodal reward contingency signals during rule-reversal. bioRxiv. (Submitted)

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DOI: 10.1101/2023.09.12.557267


While animals readily adjust their behavior to adapt to relevant changes in the environment, the neural pathways enabling these changes remain largely unknown. Here, using multiphoton imaging, we investigated whether feedback from the piriform cortex to the olfactory bulb supports such behavioral flexibility. To this end, we engaged head-fixed mice in a multimodal rule-reversal task guided by olfactory and auditory cues. Both odor and, surprisingly, the sound cues triggered cortical bulbar feedback responses which preceded the behavioral report. Responses to the same sensory cue were strongly modulated upon changes in stimulus-reward contingency (rule reversals). The re-shaping of individual bouton responses occurred within seconds of the rule-reversal events and was correlated with changes in the behavior. Optogenetic perturbation of cortical feedback within the bulb disrupted the behavioral performance. Our results indicate that the piriform-to-olfactory bulb feedback carries reward contingency signals and is rapidly re-formatted according to changes in the behavioral context.

Item Type: Paper
Subjects: organism description > animal behavior
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Albeanu lab
CSHL labs > Banerjee lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 13 September 2023
Date Deposited: 04 Oct 2023 18:48
Last Modified: 28 Dec 2023 19:59
PMCID: PMC10515864
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