Long-range population dynamics of anatomically defined neocortical networks

Chen, Jerry L, Voigt, Fabian F, Javadzadeh, Mitra, Krueppel, Roland, Helmchen, Fritjof (May 2016) Long-range population dynamics of anatomically defined neocortical networks. eLife, 5. ISSN 2050-084X

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Abstract

The coordination of activity across neocortical areas is essential for mammalian brain function. Understanding this process requires simultaneous functional measurements across the cortex. In order to dissociate direct cortico-cortical interactions from other sources of neuronal correlations, it is furthermore desirable to target cross-areal recordings to neuronal subpopulations that anatomically project between areas. Here, we combined anatomical tracers with a novel multi-area two-photon microscope to perform simultaneous calcium imaging across mouse primary (S1) and secondary (S2) somatosensory whisker cortex during texture discrimination behavior, specifically identifying feedforward and feedback neurons. We find that coordination of S1-S2 activity increases during motor behaviors such as goal-directed whisking and licking. This effect was not specific to identified feedforward and feedback neurons. However, these mutually projecting neurons especially participated in inter-areal coordination when motor behavior was paired with whisker-texture touches, suggesting that direct S1-S2 interactions are sensory-dependent. Our results demonstrate specific functional coordination of anatomically-identified projection neurons across sensory cortices.

Item Type:	Paper
Subjects:	organism description > animal behavior organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > tissues types and functions > neocortex
CSHL Authors:	Javadzadeh, Mitra
Communities:	CSHL labs > Javadzadeh lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	24 May 2016
Date Deposited:	04 Oct 2023 13:39
Last Modified:	29 Dec 2023 16:29
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41128

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