Tumor-on-chip modeling of organ-specific cancer and metastasis

Del Piccolo, Nuala, Shirure, Venktesh S, Bi, Ye, Goedegebuure, S Peter, Gholami, Sepideh, Hughes, Christopher CW, Fields, Ryan C, George, Steven C (August 2021) Tumor-on-chip modeling of organ-specific cancer and metastasis. Advanced Drug Delivery Reviews, 175. p. 113798. ISSN 0169-409X

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Abstract

Every year, cancer claims millions of lives around the globe. Unfortunately, model systems that accurately mimic human oncology - a requirement for the development of more effective therapies for these patients - remain elusive. Tumor development is an organ-specific process that involves modification of existing tissue features, recruitment of other cell types, and eventual metastasis to distant organs. Recently, tissue engineered microfluidic devices have emerged as a powerful in vitro tool to model human physiology and pathology with organ-specificity. These organ-on-chip platforms consist of cells cultured in 3D hydrogels and offer precise control over geometry, biological components, and physiochemical properties. Here, we review progress towards organ-specific microfluidic models of the primary and metastatic tumor microenvironments. Despite the field's infancy, these tumor-on-chip models have enabled discoveries about cancer immunobiology and response to therapy. Future work should focus on the development of autologous or multi-organ systems and inclusion of the immune system.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders diseases & disorders > neoplasms diseases & disorders > cancer > metastasis
CSHL Authors:	Gholami, Sepideh
Communities:	CSHL labs > Gholami Lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	August 2021
Date Deposited:	29 Sep 2023 19:36
Last Modified:	23 Jan 2024 19:35
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41083

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