Locoregional Liver-Directed Therapies to Treat Unresectable Colorectal Liver Metastases: A Review

McFadden, Nikia R, Perry, Lauren M, Ghalambor, Tara J, Langan, Russell C, Gholami, Sepideh (February 2022) Locoregional Liver-Directed Therapies to Treat Unresectable Colorectal Liver Metastases: A Review. Oncology (Williston Park, N.Y.), 36 (2). pp. 108-114. ISSN 0890-9091

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Abstract

An estimated 70% of patients with colorectal cancer will develop liver metastases during the course of their disease. While the first-line treatment for hepatic metastases is resection, most patients with colorectal liver-only or liver-dominant metastases (CRLM) present with unresectable disease and are not surgical candidates. In the past decade, locoregional liver-directed therapies have demonstrated safety and efficacy in the treatment of patients with unresectable CRLM and chemotherapy-refractory disease. These treatments can be used to attempt conversion to surgical resectability, can control local disease progression, and have the potential to prolong survival. However, they have not yet become the standard of care in many practices. Each treatment has unique risks, and the clinical data are heterogeneous and thus difficult to interpret. In this article, we will review the most recent, high-impact literature on 3 common locoregional therapies used in the treatment of patients with unresectable CRLM: hepatic artery infusion pump chemotherapy, stereotactic body radiation therapy, and selective internal radiation therapy with yttrium-90 embolization. Ultimately, for this patient population, clinical decision-making requires a multidisciplinary discussion which should take into account individual patient characteristics and clinical expertise available at the treatment facility.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders Investigative techniques and equipment diseases & disorders > neoplasms Investigative techniques and equipment > radiation treatment and equipment diseases & disorders > cancer > cancer types > colon cancer diseases & disorders > cancer > cancer types > colon cancer diseases & disorders > cancer > cancer types > liver cancer diseases & disorders > cancer > cancer types
CSHL Authors:	Gholami, Sepideh
Communities:	CSHL labs > Gholami Lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	8 February 2022
Date Deposited:	27 Sep 2023 20:06
Last Modified:	16 Jan 2024 19:04
PMCID:	PMC10030047
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/41016

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