Zilbauer, Matthias, James, Kylie R, Kaur, Mandeep, Pott, Sebastian, Li, Zhixin, Burger, Albert, Thiagarajah, Jay R, Burclaff, Joseph, Jahnsen, Frode L, Perrone, Francesca, Ross, Alexander D, Matteoli, Gianluca, Stakenborg, Nathalie, Sujino, Tomohisa, Moor, Andreas, Bartolome-Casado, Raquel, Bækkevold, Espen S, Zhou, Ran, Xie, Bingqing, Lau, Ken S, Din, Shahida, Magness, Scott T, Yao, Qiuming, Beyaz, Semir, Arends, Mark, Denadai-Souza, Alexandre, Coburn, Lori A, Gaublomme, Jellert T, Baldock, Richard, Papatheodorou, Irene, Ordovas-Montanes, Jose, Boeckxstaens, Guy, Hupalowska, Anna, Teichmann, Sarah A, Regev, Aviv, Xavier, Ramnik J, Simmons, Alison, Snyder, Michael P, Wilson, Keith T, Gut Cell Atlas Consortium, Human Cell Atlas Gut Biological Network Consortium (September 2023) A Roadmap for the Human Gut Cell Atlas. Nature Reviews Gastroenterology & Hepatology, 20 (9). pp. 597-614. ISSN 1759-5045
Abstract
The number of studies investigating the human gastrointestinal tract using various single-cell profiling methods has increased substantially in the past few years. Although this increase provides a unique opportunity for the generation of the first comprehensive Human Gut Cell Atlas (HGCA), there remains a range of major challenges ahead. Above all, the ultimate success will largely depend on a structured and coordinated approach that aligns global efforts undertaken by a large number of research groups. In this Roadmap, we discuss a comprehensive forward-thinking direction for the generation of the HGCA on behalf of the Gut Biological Network of the Human Cell Atlas. Based on the consensus opinion of experts from across the globe, we outline the main requirements for the first complete HGCA by summarizing existing data sets and highlighting anatomical regions and/or tissues with limited coverage. We provide recommendations for future studies and discuss key methodologies and the importance of integrating the healthy gut atlas with related diseases and gut organoids. Importantly, we critically overview the computational tools available and provide recommendations to overcome key challenges.
| Item Type: | Paper |
|---|---|
| Subjects: | Investigative techniques and equipment organism description > animal Investigative techniques and equipment > cell culture > cancer organoids Investigative techniques and equipment > cell culture organism description > animal > mammal > primates > hominids organism description > animal > mammal > primates > hominids > human organism description > animal > mammal organism description > animal > mammal > primates |
| CSHL Authors: | |
| Communities: | CSHL labs > Beyaz lab CSHL Cancer Center Program CSHL Cancer Center Program > Cancer Genetics and Genomics Program |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | September 2023 |
| Date Deposited: | 22 Sep 2023 15:27 |
| Last Modified: | 29 Apr 2024 18:50 |
| PMCID: | PMC10527367 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/40977 |
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